BIOINFORMATICS INVESTIGATION OF VIRULENCE FACTORS OF PROPIONIBACTERIUM ACNES TARGETED BY EPIGALLOCATECHIN-3GALLATE (EGCG)

Praja, Rian Ka and Rosalina, Reny (2023) BIOINFORMATICS INVESTIGATION OF VIRULENCE FACTORS OF PROPIONIBACTERIUM ACNES TARGETED BY EPIGALLOCATECHIN-3GALLATE (EGCG). In: Proceeding of The 1st Polkesraya International Conference. Poltekkes Kemenkes Palangka Raya, Palangka Raya, pp. 126-134. ISBN 2987-8659

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Abstract

Purpose: This study aimed to investigate and analyze virulence factors of Propionibacterium acnes targeted by phytocompound epigallocatechin-3-gallate (EGCG).

Methodology: Several bioinformatics approaches were employed to identify the targets, and evaluate their functional role and virulence property. Additionally, the BepiPred program v.2 was used to identify the peptide epitopes found in the virulence factors. PSORTb v.3 was also used to uncover the subcellular localization of the virulence factors of P. acnes.

Findings: EGCG was found to target several virulence factors of P. acnes such as Ser/Thr protein kinase, ABC transporter-associated permease, and methylated-DNA--protein-cysteine methyltransferase important for the survival of P. acnes.

Limitation: This study was computational research. Therefore, several laboratory experiments are needed to prove this bioinformatics finding.

Contribution: The finding of this study may contribute to the advancement of natural product investigation by uncovering molecular mechanisms of EGCG against P. acnes.

Keywords: Bioinformatics, Epigallocatechin-3-gallate (EGCG), Propionibacterium acnes, Virulence factors.

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