Antimycobacterial activity of Gynura procumbens leaves extract against Mycobacterium tuberculosis

Isrul, Muhammad and Idrus, Muhammad and Mashar, Harlyanti Muthmainnah and Muthmainnah, Ayu (2018) Antimycobacterial activity of Gynura procumbens leaves extract against Mycobacterium tuberculosis. International Journal of Green Pharmacy, 12 (3). pp. 163-167. ISSN 1998-4103

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Abstract

Introduction: Tuberculosis (TB) has existed for millennia and remains a major global health problem. The main challenge of TB treatment is the resistance of Mycobacterium tuberculosis. Therefore, there is a need to develop new drugs to combat those resistant M. tuberculosis. Continuous efforts are underway in the search for novel bioactive compounds and bioactive compounds of natural origin, particularly from plants, are gaining significance. Gynura procumbens is one of the plants used as traditional medicine. In Konawe district of Southeast Sulawesi, Indonesia, G. procumbens leave had been used as TB treatment. The present study was designed to investigate the antimycobacterial activity of G. procumbens leaves extract and its phytochemical composition. Materials and Methods: G. procumbens Leaves were extracted by maceration, and antimycobacterial evaluation was conducted using microscopic observation drug susceptibility method. Results: G. procumbens extract at 500 ppm has antimycobacterial activity against M. tuberculosis Strain H37Rv and multidrug-resistant. Phytochemical screening of the extract revealed the presence of flavonoids and terpenes. Conclusion: The study revealed G. procumbens extract potentially to be developed as a traditional medicine formulation for TB treatment and further studies on isolation of active principles from extracts, and their bioactive determinations are to be carried out.

Item Type:	Jurnal Artikel
Uncontrolled Keywords:	Gynura procumbens, microscopic observation drug susceptibility, Mycobacterium tuberculosis, tuberculosis
Subjects:	06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060502 Infectious Agents 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110899 Medical Microbiology not elsewhere classified 11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified
Divisions:	Jurusan Gizi > Program Studi Diploma III Gizi
Depositing User:	Harlyanti Muthma'innah Mashar
Date Deposited:	04 Nov 2019 07:06
Last Modified:	06 Nov 2019 03:18
URI:	http://repo.polkesraya.ac.id/id/eprint/66

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